Cellular and Molecular Toxicology and In Vitro Toxicology

Přední strana obálky
CRC Press, 22. 8. 1990 - Počet stran: 176
This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.
 

Co říkají ostatní - Napsat recenzi

Na obvyklých místech jsme nenalezli žádné recenze.

Obsah

The Vascular Toxicity of Xenobiotics
1
The Molecular and Cellular Toxicology of Ethanol on the Heart
19
Mechanisms of Anthracycline Cardiotoxicity Are Metabolites Involved?
51
Cardiotoxicity of Catecholamines
83
The Toxic Effects of Cocaine on the Heart
121
Cellular and Molecular Basis of XenobioticInduced Cardiovascular Toxicity Application of Cell Culture Systems
139
Index
157
Autorská práva

Další vydání - Zobrazit všechny

Běžně se vyskytující výrazy a sousloví

Oblíbené pasáže

Strana 153 - Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury.
Strana 153 - Smooth muscle phenotypic changes in arterial wall homeostasis: implications for the pathogenesis of atherosclerosis. Exp Mol Pathol 42 : 139 - 162 Campbell GR, Campbell JH (1987) Smooth muscle cells.

Bibliografické údaje