Cellular and Molecular Toxicology and In Vitro ToxicologyCRC Press, 22. 8. 1990 - Počet stran: 176 This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas. |
Obsah
The Vascular Toxicity of Xenobiotics | 1 |
The Molecular and Cellular Toxicology of Ethanol on the Heart | 19 |
Mechanisms of Anthracycline Cardiotoxicity Are Metabolites Involved? | 51 |
Cardiotoxicity of Catecholamines | 83 |
The Toxic Effects of Cocaine on the Heart | 121 |
Cellular and Molecular Basis of XenobioticInduced Cardiovascular Toxicity Application of Cell Culture Systems | 139 |
157 | |
Další vydání - Zobrazit všechny
Cellular and Molecular Toxicology and In Vitro Toxicology Daniel Acosta Náhled není k dispozici. - 1990 |
Cellular and Molecular Toxicology and in Vitro Toxicology Daniel Acosta Náhled není k dispozici. - 2017 |
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activity acute Adriamycin allylamine alterations animal anthracycline anthracycline cardiotoxicity aortic arrhythmias atrial Biochem Biol blood pressure calcium Cancer Cardiol cardiotoxicity Cardiovasc cardiovascular catecholamine-induced catecholamines cell culture cellular changes Chem chronic alcoholics chronic ethanol Clin clinical cocaine cocaine-induced concentrations contractile contraction band lesions coronary arteries daunorubicin decrease dogs doxorubicin drug effects of cocaine effects of ethanol endothelial cells enzyme ethanol experimental free radical function glutathione heart disease increased induced ingestion inhibition inhibitors injections inotropic ischemic isolated isoproterenol left ventricular lipid peroxidation liver lysyl oxidase mechanisms membrane metabolism metabolites mg/kg mitochondria molecular morphological myocardial cells myocardial infarction myocardial injury myocardial necrosis myocardium myocytes myocytolysis myofibrillar necrosis oxidase oxidative paradiscal Pathol permeability Pharmacol plasma Proc protein rabbit rat heart reduced reported response Rona sarcoplasmic reticulum smooth muscle cells systolic tion tissue toxic effects Toxicol Toxicology toxins ultrastructural vascular smooth muscle verapamil vitro vivo xenobiotics