Multiple SclerosisJürg Kesselring Cambridge University Press, 1997 - Počet stran: 214 This concise, abundantly illustrated text provides a complete overview of multiple sclerosis. By including recent research findings in genetics, immunology and pathophysiology, the authors provide reliable and up-to-date guidance on the epidemiology, diagnosis, prognosis and treatment of MS. Of particular interest to neuroscientists and neurologists will be the reviews of experimental models of MS, pathology of the demyelinated plaque, HLA associations and the role of immune mechanisms. Contributors analyze the environmental and geographical factors in the etiology of MS, including the possible role of infectious agents. The clinical sections of the book include discussion of neurological, sexual, psychological and cognitive disturbances. A review of diagnostic criteria and rehabilitation measures are prominent features of this highly practical book. |
Obsah
Historical perspective | 3 |
Pathology and experimental models | 7 |
Genetics and immunology | 30 |
Epidemiology | 47 |
Pathogenesis | 52 |
Pathophysiology of impaired neural transmission | 61 |
Clinical aspects | 67 |
Symptomatology | 69 |
Prognosis | 119 |
Differential diagnosis | 123 |
Assessment of performance ability and disability | 129 |
Management and therapy | 131 |
Symptomatic treatment and nutrition | 133 |
Therapy | 146 |
Assessment Scales | 167 |
References | 177 |
Běžně se vyskytující výrazy a sousloví
activity acute Ann Neurol antibodies antigens Arch Neurol astrocytes autoimmune axons azathioprine blood-brain barrier brain brainstem central Chapter chronic progressive clinical course cytokines deficits demyelinating lesions detected detrusor diag diagnosis differential disability disease onset EDSS effect encephalomyelitis evoked potentials exacerbation examination experimental factors frequently function genetic immune system immunoglobulin immunological increased induced infection inflammatory Kappos Kesselring Kurtzke latency lead lesions macrophages magnetic resonance imaging McDonald WI ment methylprednisolone micturition mitoxantrone models molecules motor multiple scle multiple sclerosis muscle myelin sheaths nerve fibers nervous system Neurol Neurosurg Psychiat neurological normal occur oligoclonal bands oligodendrocytes optic neuritis pathogenesis pathological patients peripheral physiotherapy placebo Poser Prineas protein reaction receptor reflex relapsing remitting response role secondary progressive sions spasticity specific sphincter spinal cord steroids stimulation studies symptoms syndromes T-cells T-lymphocytes therapeutic therapy tients tion tissue treatment viral virus visual white matter
Oblíbené pasáže
Strana 203 - Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 12, 809-837.