Receptors of Cell Adhesion and Cellular RecognitionA.G. Lee Elsevier, 25. 6. 1996 - Počet stran: 319 Volume 3 of Biomembranes covers receptors of cell adhesion and cellular recognition. Proteins in the plasma membrane of cells are heavily involved in processes of cell adhesion, but such proteins were not actually isolated and characterized until the mid-1970s. Since then, application of the methods of molecular biology has led to the recognition of four major classes of cell adhesion molecule (CAMs), the immunoglobulin super family, the cadherins, the integrins, and the selecting. A convenient system in which to study the importance of cell adhesion is in blood platelets where aggregation eventually leads to thrombus formation in a process involving a range of surface glycoproteins. Interaction with the extracellular matrix is exemplified by CD44, the receptor for hyaluronan, and a complex carbohydrate that is a major component of the extracellular matrix surrounding migrating and proliferating cells. Membrane-associated mucins have a variety of effects on cell adhesion. The super family of immunoglobulin related proteins also include the T cell receptors and the major histocompatibility complex (MHC), which, together with the receptors for immunoglobulins (the Fc receptors), are of fundamental importance in the processes of immunity. Volume 3 of Biomembranes explores the structures and functions of the molecules involved in these important functions of the cell. |
Obsah
77 | |
105 | |
127 | |
CHAPTER 6 THE INTEGRIN FAMILY | 159 |
CHAPTER 7 THE SELECTIN FAMILY | 183 |
205 | |
CHAPTER 9 MEMBRANEASSOCIATED MUCINS | 219 |
231 | |
269 | |
315 | |
Běžně se vyskytující výrazy a sousloví
Acad activation affinity aggregation amino acid antigen antigen receptor associated binding Biochem cadherins calcium carbohydrate catenin cDNA cell adhesion molecule Cell Biol cell lines cell receptor cell surface cell–cell cellular chain characterized Chem cloning complex cytoplasmic cytoplasmic domain cytoplasmic tail cytoskeleton desmosomal E-cadherin Edelman encoding endothelial cells episialin epithelial cells epitope exon expression extracellular domain factor FceRI FcyR FcyRII fibrinogen fibronectin function gene glycosylation Goridis GPIb GPIIb-IIIa homology homophilic human hyaluronan identified Ig-like domain immunoglobulin immunoglobulin superfamily Immunol inhibit integrin interaction involved isoforms Jutila L-selectin leukocyte ligand lymphocyte macrophages mediated molecular monoclonal antibodies monocytes mouse MPHC mRNA N-CAM Natl NCAM neural cell adhesion neurite outgrowth neurons neutrophils o-catenin peptide phosphorylation platelet glycoprotein polypeptide Proc protein recognition region regulation residues role Schachner selectins sequence signal transduction specific structure studies subunit superfamily Takeichi thrombin tissue transfected transmembrane tumor tyrosine kinases vivo Walsh
Oblíbené pasáže
Strana 23 - Seed B. 1989. Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins.