Molecular Nuclear Medicine: The Challenge of Genomics and Proteomics to Clinical Practice

Přední strana obálky
Ludwig E. Feinendegen, W. W. Shreeve, W. C. Eckelman
Springer Science & Business Media, 2003 - Počet stran: 795

Nuclear Medicine techniques have advanced to such a degree that biochemical transparency of the human body has reached the doorstep of medical application. The book gives background, techniques and examples in an interdisciplinary approach to quantify biochemical reactions in vivo by regional imaging and in vitro analyses. The goal is to assess in vivo biochemical homeostatic circuits under control by genes and protein interactions. It becomes apparent how nuclear medicine can aid clinical researchers and practitioners, human geneticists and pharmacologists in understanding (and affecting) gene-phenotype relationships operating in vivo and thus can help eventually to bring functional genomics and proteomics to clinical medicine.

 

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Obsah

Measurements of Biochemical Reactions
3
EBERHARD PASSARGE
31
How Proteins Speak with One Another
67
Instrumentation for Measuring Metabolism
99
Modelling Metabolite and Tracer Kinetics
121
Compound Delivery and Local Blood Flows
171
39
195
Endothelium and Compound Transfer
201
Figure and 3 Tables
327
17
353
Imaging Studies in Substance Abuse
443
Lung
487
Functional Genomics and the Liver
527
Molecular Gastrointestinal Scintigraphy 563 30 The Role of Nuclear Medicine
715
LEON S MALMUD 31 MR Contrast Agents for Molecular
721
Biomolecular Magnification Imaging 32 Magnetic and Optical Molecular Imaging
741

11
208
Molecular Imaging of Infection
233
Element Metabolism and Body Composition
253

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O autorovi (2003)

Over six hundred fifty scientific publications, especially on cell biology, molecular nuclear medicine for in vivo analysis of biochemical reactions, cell responses to low doses of ionizing radiation and to strong static magnetic fields in single- and multi- cellular systems. - Member of numerous national and international advisory groups, committees, boards. Member, Northrhine-Westfalian Academy of Sciences, Germany. Vice-president, Committee for the Annual Meetings of Nobel Prize Winners in Lindau, Germany. Numerous scientific awards and prices.

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